BIO400 Protein Folding Problem (undergrad/grad) 2007 MIT
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MIT
Instructor:
Prof. Jonathan King Level Undergraduate / Graduate
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Model pathway for a newly synthesized polypeptide chain emerging from the ribosome and folding to its native state, as well as an off-pathway inactive aggregated state. (Image by Prof. Jonathan King.)
Course Description
This course focuses on the mechanisms by which the amino acid sequence
of polypeptide chains (proteins), determine their three-dimensional
conformation. Topics in this course include sequence determinants of
secondary structure, the folding of newly synthesized polypeptide
chains within cells, folding intermediates aggregation and competing
off-pathway reactions, and the unfolding and refolding of proteins in vitro.
Additional topics covered are the role of helper proteins such as
chaperonins and isomerases, protein recovery problems in the
biotechnology industry, and diseases found associated with protein
folding defects.
Course Resources
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Copyright 2007,
by the Contributing Authors.
Cite/attribute Resource.
administrator. (2009, April 25). BIO400 Protein Folding Problem (undergrad/grad) 2007 MIT. Retrieved March 12, 2010, from Free University Courses OCW Courses OpenCourseWare Freeversity Foundation Web site: http://freeversity.org/science-and-mathematics/biology/protein-folding-problem-7.88j-7.24j-5.48j-10.543j.
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